DBN1

Across TCGA cell cohorts, DBN1 mutation is significantly associated with the RNA expression of many other genes, with 395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DBN1-associated genes across cancer lineages are FAM205A, CEACAM4, and ASB10. Each is linked with DBN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DBN1-to-partner and partner-to-DBN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205A grouped by DBN1-low versus DBN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBN1→partner) and Y-score (partner→DBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM205A →	+0.020	+2.859	<.001	<.001	3	2
PANCREAS	CEACAM4 →	+0.029	+4.237	.003	.006	3	1
PANCREAS	ASB10 →	+0.012	+4.614	<.001	.004	3	1
PANCREAS	GABRG1 →	+0.026	+4.786	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	DEFA6 →	+0.058	+4.209	.002	.006	3	1
CNS	CCL1 →	+0.255	+3.302	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 395 associations by consensus.

FAM205A by DBN1 expression — LARGE_INTESTINE

Explore this box plot interactively →