Across TCGA pan-cancer cohorts, DBIP2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of DBIP2’s most consistent transcriptional readouts.
The strongest signal is observed in cholangiocarcinoma (CHOL), where DBIP2 RNA is repressed in tumor relative to normal tissue. In most cancer types DBIP2 is over-expressed in tumor, although a few such as CHOL show the opposite, repressed pattern.
CHOL and LUSC are the cancer types where DBIP2 tumor–normal differential expression is most reproducible.