DBI

Across TCGA pan-cancer cohorts, DBI mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated DBI data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DBI mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DBI expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and GBM are the cancer types where DBI mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.716	0.374	<.001	115	view →
LSCC	DFS	Median	II,III,IV	0.883	0.663	.006	13	view →
GBM	DFS	Median	All	0.242	0.493	.007	7	view →
LUAD	DFS	Tertile	III,IV	0.358	0.899	.012	7	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
UCEC	DFS	Tertile	All	0.969	0.780	.021	6	view →
CCRCC	DFS	Tertile	All	0.603	0.854	.037	3	view →
HNSC	DFS	Tertile	II,III,IV	0.912	0.985	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

DBI–PDAC (OS)

Open the PDAC breakdown →