DBH

Across TCGA patient cohorts, DBH mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DBH-associated genes across cancer lineages are PCNA, MEK1, and Smad4. Each is linked with DBH in more than 1 cancer types. Because this analysis shows association rather than direction, both DBH-to-partner and partner-to-DBH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DBH-low versus DBH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBH→partner) and Y-score (partner→DBH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.210	+2.906	.009	.001	3	2
SKCM	MEK1 →	+0.372	+2.321	.010	.006	3	1
SKCM	Smad4 →	+0.092	+2.204	.048	.031	3	1
SKCM	4E-BP1_pT37_T46 →	-0.354	-2.321	.032	.033	3	1
UCEC	Notch1 →	+0.106	+1.594	.044	.021	3	1
UCEC	RAD51 →	+0.110	+2.999	.036	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PCNA by DBH expression — UCEC

Explore this box plot interactively →