DBH

Across TCGA cell cohorts, DBH RNA expression is significantly associated with the go_rna of many other GO terms, with 2,850 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DBH-associated GO terms across cancer lineages are Positive regulation of double-strand break repair via homologous recombination, Positive regulation of DNA-templated transcription initiation, and RNA polymerase II preinitiation complex assembly. Each is linked with DBH in more than 7 cancer types. Because this analysis shows association rather than direction, both DBH-to-partner and partner-to-DBH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair via homologous recombination grouped by DBH-low versus DBH-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DBH→partner) and Y-score (partner→DBH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of double-strand break repair via homologous recombination →	+0.094	+0.565	<.001	.002	3	8
BONE	Positive regulation of DNA-templated transcription initiation →	+0.083	+0.272	<.001	<.001	3	8
SOFT_TISSUE	RNA polymerase II preinitiation complex assembly →	+0.046	+0.362	<.001	.003	3	7
BLOOD_Lymphoma	Transcription initiation at RNA polymerase II promoter →	+0.057	+0.148	<.001	.006	2	8
OVARY	DNA replication-dependent chromatin disassembly →	+0.083	+0.064	.001	<.001	3	6
SOFT_TISSUE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.107	+0.458	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,850 associations by consensus.

Positive regulation of double-strand break repair via homologous recombination by DBH expression — SOFT_TISSUE

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