DBH

Across TCGA cell cohorts, DBH mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DBH-associated genes across cancer lineages are OR10G7, ZCCHC13, and SUPT20HL1. Each is linked with DBH in more than 1 cancer types. Because this analysis shows association rather than direction, both DBH-to-partner and partner-to-DBH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G7 grouped by DBH-low versus DBH-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DBH→partner) and Y-score (partner→DBH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10G7 →	+0.009	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	ZCCHC13 →	+0.014	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	SUPT20HL1 →	+0.005	+3.947	.007	.004	3	1
OVARY	HSF5 →	+0.006	+4.029	<.001	.009	3	1
BLOOD_Leukemia	IMPG1 →	+0.072	+3.497	<.001	.004	3	1
BLOOD_Leukemia	MARK1 →	+0.841	+3.534	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

OR10G7 by DBH expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →