Across TCGA pan-cancer cohorts, DAZ4 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of DAZ4’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where DAZ4 RNA is repressed in tumor relative to normal tissue. In most cancer types DAZ4 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.
STAD are the cancer types where DAZ4 tumor–normal differential expression is most reproducible.