DARS2

Across TCGA patient cohorts, DARS2 protein abundance is significantly associated with the RNA expression of many other genes, with 14,797 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DARS2-associated genes across cancer lineages are NRP1, TRIM22, and PRDM8. Each is linked with DARS2 in more than 6 cancer types. Because this analysis shows association rather than direction, both DARS2-to-partner and partner-to-DARS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DARS2 versus NRP1 in OV, with a Pearson correlation of -0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DARS2→partner) and Y-score (partner→DARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NRP1 →	-0.978	-0.463	<.001	<.001	3	7
HNSC	TRIM22 →	-1.361	-0.292	<.001	.001	3	6
COAD	PRDM8 →	-0.753	-0.365	<.001	<.001	3	6
LUAD	UBQLN4 →	+0.589	+0.420	<.001	<.001	3	6
HNSC	FLVCR1 →	+0.802	+0.360	<.001	<.001	3	6
BRCA	MAP3K5 →	-0.831	-0.509	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,797 associations by consensus.

DARS2 vs NRP1 — OV

Explore this scatter interactively →