DARS2

Across TCGA patient cohorts, DARS2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DARS2-associated genes across cancer lineages are 14-3-3_beta, GSK3-a-b, and IGFBP2. Each is linked with DARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DARS2-to-partner and partner-to-DARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by DARS2-low versus DARS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DARS2→partner) and Y-score (partner→DARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.089	-2.432	.014	.018	3	1
UCEC	GSK3-a-b →	-0.121	-2.459	.013	.019	3	1
UCEC	IGFBP2 →	-0.670	-1.584	.004	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.131	-1.571	.030	.019	3	1
UCEC	JNK2 →	+0.219	+2.321	.002	.001	3	1
UCEC	MEK1 →	+0.404	+2.321	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

14-3-3_beta by DARS2 expression — UCEC

Explore this box plot interactively →