DARS2

Across TCGA cell cohorts, DARS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,475 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DARS2-associated GO terms across cancer lineages are DNA replication initiation, Asparaginyl-tRNA aminoacylation, and Nucleocytoplasmic transport. Each is linked with DARS2 in more than 16 cancer types. Because this analysis shows association rather than direction, both DARS2-to-partner and partner-to-DARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by DARS2-low versus DARS2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DARS2→partner) and Y-score (partner→DARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNA replication initiation →	+0.187	+1.161	<.001	<.001	3	17
OESOPHAGUS	Asparaginyl-tRNA aminoacylation →	+0.201	+1.113	.001	.001	3	17
OVARY	Nucleocytoplasmic transport →	+0.065	+0.998	.002	.002	3	16
SOFT_TISSUE	DNA strand elongation involved in DNA replication →	+0.190	+1.072	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	'de novo' IMP biosynthetic process →	+0.151	+1.135	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.188	+1.428	.001	<.001	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,475 associations by consensus.

DNA replication initiation by DARS2 expression — PANCREAS

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