DARS2

Across TCGA cell cohorts, DARS2 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DARS2-associated genes across cancer lineages are ADH1A, ANO5, and REG1B. Each is linked with DARS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DARS2-to-partner and partner-to-DARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADH1A grouped by DARS2-low versus DARS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DARS2→partner) and Y-score (partner→DARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADH1A →	+0.112	+2.920	<.001	.001	3	2
LARGE_INTESTINE	ANO5 →	+0.769	+2.938	<.001	.003	3	1
LARGE_INTESTINE	REG1B →	+2.644	+3.196	<.001	<.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	1
LARGE_INTESTINE	FAM205A →	+0.018	+3.444	<.001	.001	3	1
LARGE_INTESTINE	KLF18 →	+0.006	+3.023	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ADH1A by DARS2 expression — LARGE_INTESTINE

Explore this box plot interactively →