DARS1

Across TCGA pan-cancer cohorts, DARS1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DARS1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DARS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DARS1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LUAD, LSCC, and CCRCC are the cancer types where DARS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.593	0.903	<.001	49	view →
LSCC	OS	Median	II,III,IV	1.000	0.888	.027	5	view →
CCRCC	DFS	Median	All	0.850	0.600	.025	4	view →
PDAC	OS	Quartile	All	0.277	0.442	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DARS1–LUAD (OS)

Open the LUAD breakdown →