DARS1

Across TCGA patient cohorts, DARS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,813 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DARS1-associated proteins across cancer lineages are SPCS3, TBC1D9_S471, and KDM3A. Each is linked with DARS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DARS1-to-partner and partner-to-DARS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DARS1 versus SPCS3 in LSCC, with a Pearson correlation of -0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DARS1→partner) and Y-score (partner→DARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPCS3 →	-0.479	-0.438	<.001	<.001	3	5
BRCA	TBC1D9_S471 →	-0.943	-0.482	<.001	<.001	3	5
LSCC	KDM3A →	+0.547	+0.520	<.001	<.001	3	5
LSCC	SEC11C →	-0.784	-0.355	<.001	<.001	3	5
HNSC	METTL7A →	-0.575	-0.533	.001	.003	3	5
LSCC	IGF2BP2 →	+0.849	+0.437	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,813 associations by consensus.

DARS1 vs SPCS3 — LSCC

Explore this scatter interactively →