DARS1

Across TCGA patient cohorts, DARS1 protein abundance is significantly associated with the RNA expression of many other genes, with 20,245 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DARS1-associated genes across cancer lineages are CLEC1A, PODN, and DCN. Each is linked with DARS1 in more than 7 cancer types. Because this analysis shows association rather than direction, both DARS1-to-partner and partner-to-DARS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DARS1 versus CLEC1A in UCEC, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DARS1→partner) and Y-score (partner→DARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLEC1A →	-0.773	-0.160	<.001	<.001	3	8
OV	PODN →	-1.580	-0.288	<.001	<.001	3	8
CCRCC	DCN →	-2.074	-0.356	<.001	<.001	3	7
PDAC	COL14A1 →	-1.311	-0.193	<.001	<.001	3	7
OV	TPI1 →	+0.562	+0.267	.004	.001	3	7
OV	FGF7 →	-1.194	-0.259	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,245 associations by consensus.

DARS1 vs CLEC1A — UCEC

Explore this scatter interactively →