DARS1

Across TCGA patient cohorts, DARS1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DARS1-associated genes across cancer lineages are GAPDH, ERK2, and INPP4B. Each is linked with DARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DARS1-to-partner and partner-to-DARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by DARS1-low versus DARS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DARS1→partner) and Y-score (partner→DARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.507	+2.115	.030	.019	3	2
UCEC	ERK2 →	+0.228	+3.169	.006	.018	3	1
UCEC	INPP4B →	-0.356	-3.169	.011	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.147	-2.321	.045	.034	3	1
UCEC	MEK1 →	+0.357	+2.999	.025	.035	3	1
UCEC	mTOR_pS2448 →	-0.180	-2.986	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

GAPDH by DARS1 expression — UCEC

Explore this box plot interactively →