DARS1

Across TCGA cell cohorts, DARS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,694 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible DARS1-associated GO terms across cancer lineages are Centromeric sister chromatid cohesion, Regulation of centriole replication, and Regulation of chromosome separation. Each is linked with DARS1 in more than 10 cancer types. Because this analysis shows association rather than direction, both DARS1-to-partner and partner-to-DARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centromeric sister chromatid cohesion grouped by DARS1-low versus DARS1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DARS1→partner) and Y-score (partner→DARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Centromeric sister chromatid cohesion →	+0.142	+0.522	.008	.007	3	11
LUNG_NSCLC_LUSC	Regulation of centriole replication →	+0.085	+0.696	<.001	<.001	3	10
BREAST	Regulation of chromosome separation →	+0.122	+0.665	.002	.004	3	9
BLOOD_Leukemia	Regulation of tRNA catabolic process →	-0.114	-0.452	<.001	.004	3	9
BLOOD_Leukemia	Negative regulation of tRNA catabolic process →	-0.114	-0.452	<.001	.004	3	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of centriole replication →	+0.104	+0.790	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,694 associations by consensus.

Centromeric sister chromatid cohesion by DARS1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →