DAPP1

Across TCGA pan-cancer cohorts, DAPP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DAPP1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DAPP1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DAPP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where DAPP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.838	0.586	.006	31	view →
PDAC	OS	Median	III,IV	0.591	0.976	.002	15	view →
CCRCC	DFS	Quartile	III,IV	0.245	0.819	.009	10	view →
LUAD	OS	Median	All	0.598	0.949	.001	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DAPP1–HNSC (OS)

Open the HNSC breakdown →