DAPP1

Across TCGA patient cohorts, DAPP1 mutation is significantly associated with the RNA expression of many other genes, with 978 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAPP1-associated genes across cancer lineages are BPNT2P, MIA-RAB4B, and SNRPCP8. Each is linked with DAPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DAPP1-to-partner and partner-to-DAPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPNT2P grouped by DAPP1-low versus DAPP1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAPP1→partner) and Y-score (partner→DAPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	BPNT2P →	+0.162	+6.681	<.001	<.001	3	2
UCEC	MIA-RAB4B →	+0.093	+2.563	<.001	<.001	3	2
SKCM	SNRPCP8 →	+0.163	+2.392	.004	.006	3	2
UCEC	CHEK1 →	+0.674	+2.136	<.001	.009	3	2
UCEC	VBP1 →	+0.524	+2.108	.007	.003	3	2
UCEC	AK8 →	-0.808	-2.087	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 978 associations by consensus.

BPNT2P by DAPP1 expression — READ

Explore this box plot interactively →