DAPP1

Across TCGA patient cohorts, DAPP1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAPP1-associated genes across cancer lineages are ERK2, EGFR_pY1068, and Acetyl-a-Tubulin-Lys40. Each is linked with DAPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DAPP1-to-partner and partner-to-DAPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by DAPP1-low versus DAPP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAPP1→partner) and Y-score (partner→DAPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.244	+1.700	.002	.044	3	2
UCEC	EGFR_pY1068 →	-0.281	-3.169	.008	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.571	+2.222	.008	.011	3	1
UCEC	MSH6 →	-0.354	-3.169	.011	.018	3	1
UCEC	mTOR_pS2448 →	-0.146	-3.308	.020	.009	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.484	-1.687	.011	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ERK2 by DAPP1 expression — UCEC

Explore this box plot interactively →