DAPK3

Across TCGA pan-cancer cohorts, DAPK3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DAPK3 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DAPK3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DAPK3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where DAPK3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.603	1.000	.018	13	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
HNSC	DFS	Tertile	II,III,IV	0.973	0.863	.032	6	view →
CCRCC	DFS	Tertile	III,IV	0.827	0.438	.015	6	view →
UCEC	OS	Median	II,III,IV	0.647	1.000	.017	4	view →
GBM	DFS	Median	All	0.275	0.466	.008	4	view →
LUAD	OS	Tertile	All	1.000	0.952	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DAPK3–LSCC (OS)

Open the LSCC breakdown →