DAPK3

Across TCGA patient cohorts, DAPK3 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAPK3-associated genes across cancer lineages are p62 Lck ligand, eIF4E, and TIGAR. Each is linked with DAPK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DAPK3-to-partner and partner-to-DAPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by DAPK3-low versus DAPK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAPK3→partner) and Y-score (partner→DAPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.451	+3.331	.002	.005	3	3
UCEC	eIF4E →	+0.202	+2.820	.033	.035	3	2
UCEC	TIGAR →	+0.150	+2.026	.029	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.831	+3.341	.001	.005	3	2
UCEC	A-Raf_pS299 →	-0.146	-3.321	.006	.010	3	1
UCEC	NF2 →	+0.243	+2.999	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

p62 Lck ligand by DAPK3 expression — UCEC

Explore this box plot interactively →