DAPK3

Across TCGA cell cohorts, DAPK3 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DAPK3-associated genes across cancer lineages are OR4X2, OR4B1, and CYP27C1. Each is linked with DAPK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DAPK3-to-partner and partner-to-DAPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by DAPK3-low versus DAPK3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAPK3→partner) and Y-score (partner→DAPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR4X2 →	+0.045	+5.029	<.001	.006	3	1
LUNG_SCLC	OR4B1 →	+0.044	+5.029	<.001	.006	3	1
BLOOD_Leukemia	CYP27C1 →	+0.040	+3.450	<.001	.004	3	1
LUNG_NSCLC_LUAD	TCP10L2 →	+0.036	+4.887	.004	.009	3	1
LUNG_NSCLC_LUAD	OR2L8 →	+0.020	+6.266	<.001	<.001	3	1
LARGE_INTESTINE	SH3GL2 →	+1.862	+3.474	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR4X2 by DAPK3 expression — LUNG_SCLC

Explore this box plot interactively →