Across TCGA patient cohorts, DAPK1 mutation is significantly associated with the RNA expression of many other genes, with 3,566 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAPK1-associated genes across cancer lineages are ECHS1, RPL12P46, and TAF9. Each is linked with DAPK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DAPK1-to-partner and partner-to-DAPK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAPK1→partner) and Y-score (partner→DAPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ECHS1 →	+0.270	+2.375	.002	<.001	3	4
BRCA	RPL12P46 →	+0.148	+4.630	<.001	.006	3	3
UCEC	TAF9 →	+0.502	+1.647	<.001	<.001	3	3
READ	MIR5089 →	+0.601	+4.653	<.001	.007	3	3
UCEC	GSR →	+0.631	+3.343	<.001	<.001	3	3
UCEC	BAG1 →	+0.381	+1.903	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,566 associations by consensus.

Exploration

DAPK1 survival (RNA) · tumor vs normal (RNA) · all DAPK1 data types