DAP3

Across TCGA pan-cancer cohorts, DAP3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DAP3 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DAP3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DAP3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and UCEC are the cancer types where DAP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.761	.014	11	view →
CCRCC	OS	Median	II,III,IV	0.931	0.702	.004	11	view →
UCEC	DFS	Tertile	II,III,IV	0.414	0.884	.021	8	view →
LUAD	DFS	Quartile	II,III,IV	0.991	0.613	.005	5	view →
HNSC	DFS	Tertile	III,IV	0.739	0.489	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DAP3–LSCC (OS)

Open the LSCC breakdown →