DAP

Across TCGA pan-cancer cohorts, DAP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DAP data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DAP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DAP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LSCC, UCEC, and GBM are the cancer types where DAP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.446	0.883	<.001	75	view →
UCEC	DFS	Tertile	All	0.976	0.806	.023	12	view →
GBM	DFS	Tertile	All	0.647	0.879	.014	4	view →
HNSC	DFS	Tertile	IV	0.629	0.916	.005	4	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
CCRCC	DFS	Quartile	All	0.633	0.895	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DAP–LSCC (DFS)

Open the LSCC breakdown →