DAOA

Across TCGA patient cohorts, DAOA mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAOA-associated genes across cancer lineages are eIF4E, Notch1, and HER2. Each is linked with DAOA in more than 1 cancer types. Because this analysis shows association rather than direction, both DAOA-to-partner and partner-to-DAOA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DAOA-low versus DAOA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAOA→partner) and Y-score (partner→DAOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.197	+3.321	.032	.010	3	2
UCEC	Notch1 →	+0.216	+3.469	<.001	.002	3	2
SKCM	HER2 →	-0.407	-3.000	.011	.036	3	1
UCEC	JNK2 →	+0.202	+2.115	.020	.019	3	1
UCEC	Ku80 →	+0.223	+1.598	.030	.044	3	1
UCEC	N-Ras →	-0.145	-3.143	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eIF4E by DAOA expression — UCEC

Explore this box plot interactively →