DAOA

Across TCGA cell cohorts, DAOA mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DAOA-associated genes across cancer lineages are IDI2, GSG1L2, and KLF18. Each is linked with DAOA in more than 1 cancer types. Because this analysis shows association rather than direction, both DAOA-to-partner and partner-to-DAOA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IDI2 grouped by DAOA-low versus DAOA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAOA→partner) and Y-score (partner→DAOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IDI2 →	+0.030	+3.994	<.001	.002	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
LARGE_INTESTINE	KLF18 →	+0.009	+4.345	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

IDI2 by DAOA expression — LARGE_INTESTINE

Explore this box plot interactively →