DAOA-AS1

Across TCGA pan-cancer cohorts, DAOA-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated DAOA-AS1 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher DAOA-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DAOA-AS1 expression acts as an unfavorable survival marker, although some lineages such as SARC show a favorable association.

READ, CESC, and KICH are the cancer types where DAOA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Tertile	All	0.162	0.834	<.001	126	view →
CESC	OS	Tertile	III,IV	0.215	0.764	<.001	114	view →
KICH	OS	Tertile	All	0.082	0.877	<.001	81	view →
PAAD	DFS	Tertile	All	0.155	0.490	<.001	81	view →
ACC	DFS	Tertile	IV	0.010	0.383	<.001	45	view →
LGG	OS	Tertile	All	0.767	0.903	<.001	39	view →
KIRC	DFS	Tertile	IV	0.311	0.641	.005	39	view →
ESCA	OS	Tertile	IV	0.095	0.512	.008	36	view →
THYM	OS	Tertile	All	0.186	0.931	<.001	36	view →
BLCA	OS	Tertile	IV	0.224	0.607	.003	33	view →
GBM	OS	Tertile	All	0.271	0.436	.003	27	view →
MESO	OS	Tertile	III,IV	0.197	0.668	.008	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

DAOA-AS1–READ (DFS)

Open the READ breakdown →