DAO

Across TCGA pan-cancer cohorts, DAO Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DAO data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DAO Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DAO expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, UCEC, and LIHC are the cancer types where DAO Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
UCEC	DFS	Median	II,III,IV	1.000	0.436	.014	22	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	9	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LUSC	OS	Median	II,III,IV	0.173	0.677	.029	3	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DAO–ACC (DFS)

Open the ACC breakdown →