DAO

Across TCGA patient cohorts, DAO mutation is significantly associated with the RNA expression of many other genes, with 1,236 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAO-associated genes across cancer lineages are LIN7C, EIF4E, and GPATCH11. Each is linked with DAO in more than 1 cancer types. Because this analysis shows association rather than direction, both DAO-to-partner and partner-to-DAO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIN7C grouped by DAO-low versus DAO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAO→partner) and Y-score (partner→DAO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LIN7C →	+0.494	+2.815	.009	.001	3	2
UCEC	EIF4E →	+0.390	+2.053	.009	.005	3	2
UCEC	GPATCH11 →	+0.410	+3.180	.005	<.001	3	2
UCEC	VPS37A →	+0.698	+3.180	<.001	<.001	3	2
UCEC	DCK →	+0.657	+2.010	.004	.006	3	2
UCEC	VPS26C →	+0.463	+2.600	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,236 associations by consensus.

LIN7C by DAO expression — UCEC

Explore this box plot interactively →