DAO

Across TCGA patient cohorts, DAO mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAO-associated genes across cancer lineages are Notch1, MEK1, and mTOR_pS2448. Each is linked with DAO in more than 1 cancer types. Because this analysis shows association rather than direction, both DAO-to-partner and partner-to-DAO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DAO-low versus DAO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAO→partner) and Y-score (partner→DAO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.186	+3.335	.001	.005	3	2
UCEC	MEK1 →	+0.430	+2.321	.004	.006	3	1
UCEC	mTOR_pS2448 →	-0.123	-2.302	.045	.034	3	1
UCEC	Myosin-IIa →	+0.159	+1.592	.049	.044	3	1
UCEC	p27_pT198 →	+0.095	+1.807	.031	.027	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.431	-1.794	.020	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Notch1 by DAO expression — UCEC

Explore this box plot interactively →