DANT2

Across TCGA pan-cancer cohorts, DANT2 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of DANT2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DANT2 RNA is repressed in tumor relative to normal tissue. In most cancer types DANT2 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, HNSC, and KIRC are the cancer types where DANT2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DANT2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.322	<.001	9	view →
HNSC	All	All	+0.079	.007	6	view →
KIRC	Male	All	−0.071	.020	4	view →
KIRP	All	IV	+0.100	.040	2	view →
LUSC	All	All	+0.098	.004	2	view →
COAD	Female	III,IV	−0.120	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

DANT2–THCA

Open the THCA breakdown →