DAGLB

Across TCGA cell cohorts, DAGLB mutation is significantly associated with the RNA expression of many other genes, with 276 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DAGLB-associated genes across cancer lineages are OR10A5, GUCA2A, and PCDH8. Each is linked with DAGLB in more than 1 cancer types. Because this analysis shows association rather than direction, both DAGLB-to-partner and partner-to-DAGLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A5 grouped by DAGLB-low versus DAGLB-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAGLB→partner) and Y-score (partner→DAGLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR10A5 →	+0.023	+5.000	<.001	.005	3	1
KIDNEY	GUCA2A →	+0.043	+5.000	<.001	.005	3	1
BLOOD_Leukemia	PCDH8 →	+1.296	+4.032	<.001	.001	3	1
BLOOD_Leukemia	URAD →	+0.333	+3.474	<.001	.007	3	1
BLOOD_Leukemia	AQP12A →	+0.080	+4.099	<.001	<.001	3	1
BLOOD_Leukemia	AQP12B →	+0.188	+4.189	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 276 associations by consensus.

OR10A5 by DAGLB expression — KIDNEY

Explore this box plot interactively →