DAGLB

Across TCGA cell cohorts, DAGLB mutation is significantly associated with the mutation status of many other genes, with 3,508 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DAGLB-associated genes across cancer lineages are ZNF804B, DOP1B, and IGSF10. Each is linked with DAGLB in more than 3 cancer types. Because this analysis shows association rather than direction, both DAGLB-to-partner and partner-to-DAGLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF804B grouped by DAGLB-low versus DAGLB-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAGLB→partner) and Y-score (partner→DAGLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ZNF804B →	+4.954	+4.392	.008	.008	1	4
LARGE_INTESTINE	DOP1B →	+1.321	+2.807	.002	.002	1	4
SKIN	IGSF10 →	+2.313	+3.282	.007	.007	1	4
SKIN	FANCA →	+3.035	+3.321	.008	.008	1	4
KIDNEY	HELZ2 →	+3.201	+4.426	.001	.001	1	3
PANCREAS	MYCBP2 →	+3.257	+4.362	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,508 associations by consensus.

ZNF804B by DAGLB expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →