DAG1

Across TCGA patient cohorts, DAG1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAG1-associated genes across cancer lineages are MSH6, p70-S6K_pT389, and ERK2. Each is linked with DAG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DAG1-to-partner and partner-to-DAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by DAG1-low versus DAG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAG1→partner) and Y-score (partner→DAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.315	-1.807	.003	.024	3	3
SKCM	p70-S6K_pT389 →	-0.172	-3.000	.036	.035	3	2
UCEC	ERK2 →	+0.149	+1.415	.018	.043	3	2
UCEC	ACC1 →	+0.248	+1.887	.038	.029	3	2
UCEC	JNK_pT183_Y185 →	-0.179	-1.906	.001	.014	3	2
UCEC	Rictor_pT1135 →	-0.072	-1.678	.032	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

MSH6 by DAG1 expression — UCEC

Explore this box plot interactively →