DAG1

Across TCGA cell cohorts, DAG1 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DAG1-associated genes across cancer lineages are MRGPRD, GPR101, and TPD52L3. Each is linked with DAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DAG1-to-partner and partner-to-DAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRD grouped by DAG1-low versus DAG1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAG1→partner) and Y-score (partner→DAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MRGPRD →	+0.324	+3.000	<.001	.006	3	2
BLOOD_Leukemia	GPR101 →	+0.167	+4.551	<.001	.004	3	1
BLOOD_Leukemia	TPD52L3 →	+0.009	+4.539	<.001	.007	3	1
BLOOD_Leukemia	NKX2-6 →	+0.507	+5.786	<.001	<.001	3	1
BLOOD_Leukemia	NPAP1 →	+0.075	+4.551	<.001	.004	3	1
BLOOD_Leukemia	PRR30 →	+0.024	+5.269	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

MRGPRD by DAG1 expression — CNS

Explore this box plot interactively →