DAD1

Across TCGA pan-cancer cohorts, DAD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DAD1 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DAD1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DAD1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, LSCC, and HNSC are the cancer types where DAD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.879	0.307	.008	18	view →
LSCC	DFS	Tertile	II,III,IV	0.651	0.889	.021	8	view →
HNSC	DFS	Quartile	All	0.938	0.725	.017	5	view →
OV	DFS	Quartile	All	0.942	0.657	.042	4	view →
CCRCC	OS	Tertile	All	0.706	1.000	.014	4	view →
PDAC	OS	Median	II,III,IV	0.416	0.572	.041	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DAD1–LUAD (OS)

Open the LUAD breakdown →