DAD1

Across TCGA patient cohorts, DAD1 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAD1-associated genes across cancer lineages are RNA5SP414, RNA5SP411, and RNA5SP412. Each is linked with DAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DAD1-to-partner and partner-to-DAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by DAD1-low versus DAD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAD1→partner) and Y-score (partner→DAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.859	+2.933	<.001	.006	3	1
UCEC	RNA5SP411 →	+2.333	+3.393	<.001	<.001	3	1
UCEC	RNA5SP412 →	+1.000	+3.289	<.001	.001	3	1
UCEC	HES3 →	+0.177	+3.016	<.001	.003	3	1
UCEC	MIR548AW →	+0.343	+4.437	<.001	.005	3	1
UCEC	MIR4448 →	+0.367	+3.937	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

RNA5SP414 by DAD1 expression — UCEC

Explore this box plot interactively →