DAD1

Across TCGA patient cohorts, DAD1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAD1-associated genes across cancer lineages are Ku80, PCNA, and AR. Each is linked with DAD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DAD1-to-partner and partner-to-DAD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by DAD1-low versus DAD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAD1→partner) and Y-score (partner→DAD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.400	+3.013	.003	.019	3	1
UCEC	PCNA →	+0.269	+3.000	.031	.037	3	1
UCEC	AR →	-0.479	-3.000	.026	.037	3	1
UCEC	Bak →	+0.381	+3.000	.008	.037	3	1
UCEC	Notch1 →	+0.418	+3.009	<.001	.019	2	1
UCEC	EGFR_pY1068 →	-0.288	-3.000	.047	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Ku80 by DAD1 expression — UCEC

Explore this box plot interactively →