Across TCGA pan-cancer cohorts, DACT3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DACT3 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DACT3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DACT3 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LSCC, GBM, and UCEC are the cancer types where DACT3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.361	1.000	.006	11	view →
GBM	OS	Quartile	All	0.550	0.248	.018	5	view →
UCEC	OS	Tertile	II,III,IV	0.499	1.000	.021	4	view →
LUAD	OS	Median	III,IV	0.344	0.897	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: DACT3 tumor-vs-normal RNA expression · all DACT3 data types