Across TCGA patient cohorts, DACT3 protein abundance is significantly associated with the RNA expression of many other genes, with 12,798 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DACT3-associated genes across cancer lineages are HTR2A, CNRIP1, and RECK. Each is linked with DACT3 in more than 5 cancer types. Because this analysis shows association rather than direction, both DACT3-to-partner and partner-to-DACT3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACT3→partner) and Y-score (partner→DACT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HTR2A →	+0.759	+0.340	<.001	<.001	3	6
UCEC	CNRIP1 →	+0.795	+0.913	<.001	<.001	3	6
BRCA	RECK →	+0.738	+0.820	<.001	<.001	3	6
GBM	KCNT2 →	+0.783	+0.376	.006	<.001	3	6
BRCA	ZCCHC24 →	+0.926	+0.950	<.001	<.001	3	6
UCEC	JAM3 →	+0.812	+0.928	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,798 associations by consensus.

Exploration

DACT3 survival (RNA) · tumor vs normal (RNA) · all DACT3 data types