Across TCGA patient cohorts, DACT3 protein abundance is significantly associated with the protein abundance of many other proteins, with 22,457 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DACT3-associated proteins across cancer lineages are ANK2, CYTH3, and AKAP12_T1116. Each is linked with DACT3 in more than 5 cancer types. Because this analysis shows association rather than direction, both DACT3-to-partner and partner-to-DACT3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DACT3→partner) and Y-score (partner→DACT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANK2 →	+0.600	+1.051	<.001	<.001	3	6
BRCA	CYTH3 →	+0.685	+1.228	<.001	<.001	3	6
PDAC	AKAP12_T1116 →	+1.053	+0.513	<.001	<.001	3	6
UCEC	CNRIP1 →	+0.991	+1.166	<.001	<.001	3	6
UCEC	NEXN →	+1.182	+1.292	<.001	<.001	3	6
UCEC	NEXN_S365 →	+1.282	+1.086	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,457 associations by consensus.

Exploration

DACT3 survival (RNA) · tumor vs normal (RNA) · all DACT3 data types