Across TCGA patient cohorts, DACT3 mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DACT3-associated genes across cancer lineages are RNU4-13P, MTCYBP10, and MSGN1. Each is linked with DACT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DACT3-to-partner and partner-to-DACT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACT3→partner) and Y-score (partner→DACT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-13P →	+0.168	+4.242	<.001	.006	3	2
UCEC	MTCYBP10 →	+0.043	+4.662	.002	.003	3	2
SCLC	MSGN1 →	+0.347	+4.329	<.001	.006	3	1
SCLC	OR10A5 →	+0.154	+5.432	<.001	<.001	3	1
SCLC	C10orf120 →	+0.150	+4.693	<.001	.002	3	1
SCLC	KRTAP4-9 →	+0.069	+4.502	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Exploration

DACT3 survival (RNA) · tumor vs normal (RNA) · all DACT3 data types