Across TCGA cell cohorts, DACT3 mutation is significantly associated with the RNA expression of many other genes, with 147 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DACT3-associated genes across cancer lineages are PPDPFL, OR52A5, and OR13D1. Each is linked with DACT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DACT3-to-partner and partner-to-DACT3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACT3→partner) and Y-score (partner→DACT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PPDPFL →	+1.573	+4.129	<.001	.007	3	1
SKIN	OR52A5 →	+0.028	+3.977	<.001	.001	3	1
SKIN	OR13D1 →	+0.021	+3.345	<.001	.007	3	1
SKIN	USP17L17 →	+0.006	+4.022	<.001	.006	3	1
SKIN	C19orf85 →	+0.031	+3.878	.001	.003	3	1
LARGE_INTESTINE	SRP54 →	+0.391	+3.364	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 147 associations by consensus.

Exploration

DACT3 survival (RNA) · tumor vs normal (RNA) · all DACT3 data types