DACT3-AS1

Across TCGA pan-cancer cohorts, DACT3-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated DACT3-AS1 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher DACT3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DACT3-AS1 expression acts as an unfavorable survival marker, although some lineages such as LGG and UCS show a favorable association.

LIHC, UVM, and LGG are the cancer types where DACT3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	III,IV	0.433	0.746	.001	61	view →
UVM	DFS	Quartile	II,III,IV	0.284	0.841	.002	42	view →
LGG	OS	Tertile	All	0.659	0.436	<.001	40	view →
UCS	DFS	Median	II,III,IV	0.504	0.217	.007	38	view →
COAD	OS	Median	III,IV	0.371	0.689	.003	35	view →
OV	OS	Tertile	All	0.766	0.885	.001	28	view →
ACC	OS	Tertile	All	0.460	0.925	.010	27	view →
KICH	DFS	Median	All	0.755	1.000	.018	18	view →
BLCA	OS	Quartile	III,IV	0.827	0.602	.004	17	view →
LAML	DFS	Median	All	0.524	0.252	.021	14	view →
HNSC	OS	Tertile	III,IV	0.739	0.574	.009	13	view →
GBM	OS	Quartile	All	0.539	0.308	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

DACT3-AS1–LIHC (OS)

Open the LIHC breakdown →