DACT2

Across TCGA patient cohorts, DACT2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DACT2-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and GSK3-a-b. Each is linked with DACT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DACT2-to-partner and partner-to-DACT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DACT2-low versus DACT2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACT2→partner) and Y-score (partner→DACT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.263	+3.008	.040	.019	3	2
COAD	Caspase-7-cleavedD198 →	+1.533	+3.008	<.001	.019	3	2
COAD	GSK3-a-b →	+0.165	+3.042	.037	.018	3	1
COAD	MEK1 →	+0.367	+2.824	<.001	.034	3	1
COAD	Chk2_pT68 →	-0.172	-2.974	.045	.036	2	2
UCEC	Heregulin →	-0.109	-2.115	.044	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PCNA by DACT2 expression — COAD

Explore this box plot interactively →