DACT2

Across TCGA cell cohorts, DACT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,417 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DACT2-associated GO terms across cancer lineages are Negative regulation of mRNA metabolic process, Regulation of nodal signaling pathway, and Negative regulation of nodal signaling pathway. Each is linked with DACT2 in more than 5 cancer types. Because this analysis shows association rather than direction, both DACT2-to-partner and partner-to-DACT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA metabolic process grouped by DACT2-low versus DACT2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DACT2→partner) and Y-score (partner→DACT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of mRNA metabolic process →	+0.032	+0.013	.001	.004	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of nodal signaling pathway →	-0.301	-0.856	<.001	<.001	3	5
SOFT_TISSUE	Negative regulation of nodal signaling pathway →	-0.206	-0.731	<.001	.007	3	5
BONE	Regulation of inner ear receptor cell differentiation →	+1.287	+1.706	<.001	.004	3	5
BONE	Regulation of mechanoreceptor differentiation →	+1.287	+1.706	<.001	.004	3	5
LUNG_SCLC	Regulation of macroautophagy →	+0.045	+0.793	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,417 associations by consensus.

Negative regulation of mRNA metabolic process by DACT2 expression — BLOOD_Lymphoma

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