DACT1

Across TCGA patient cohorts, DACT1 protein abundance is significantly associated with the RNA expression of many other genes, with 172 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DACT1-associated genes across cancer lineages are SMG9, BAG1, and HYAL1. Each is linked with DACT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DACT1-to-partner and partner-to-DACT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DACT1 versus SMG9 in BRCA, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACT1→partner) and Y-score (partner→DACT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SMG9 →	+0.636	+0.777	.009	.003	3	1
BRCA	BAG1 →	+1.370	+1.059	<.001	.007	3	1
BRCA	HYAL1 →	+0.459	+0.985	.005	.001	3	1
BRCA	DLGAP3 →	-0.364	-0.722	.006	.007	3	1
BRCA	SIPA1L2 →	+1.108	+1.014	.004	.006	3	1
BRCA	SORBS3 →	+1.573	+0.826	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 172 associations by consensus.

DACT1 vs SMG9 — BRCA

Explore this scatter interactively →