DACT1

Across TCGA patient cohorts, DACT1 mutation is significantly associated with the RNA expression of many other genes, with 6,803 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DACT1-associated genes across cancer lineages are GSR, GSKIP, and PSMC1. Each is linked with DACT1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DACT1-to-partner and partner-to-DACT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSR grouped by DACT1-low versus DACT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACT1→partner) and Y-score (partner→DACT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSR →	+0.702	+1.440	<.001	<.001	3	5
COAD	GSKIP →	+0.811	+3.584	<.001	.002	3	4
LUAD	PSMC1 →	+0.485	+2.333	<.001	.003	3	4
LUAD	CDCA5 →	+0.882	+3.602	.002	.001	3	4
LUAD	KPNA2 →	+0.953	+3.709	<.001	<.001	3	4
LUAD	GOLGA5 →	+0.379	+3.023	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,803 associations by consensus.

GSR by DACT1 expression — UCEC

Explore this box plot interactively →