DACT1

Across TCGA patient cohorts, DACT1 mutation is significantly associated with the total protein of many other genes, with 84 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DACT1-associated genes across cancer lineages are PAI-1, PCNA, and PDCD4. Each is linked with DACT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DACT1-to-partner and partner-to-DACT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by DACT1-low versus DACT1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACT1→partner) and Y-score (partner→DACT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PAI-1 →	+0.834	+3.017	<.001	.017	3	3
COAD	PCNA →	+0.225	+1.593	.020	.043	3	3
UCEC	PDCD4 →	-0.574	-3.321	<.001	<.001	3	3
COAD	FASN →	+0.490	+1.593	.001	.043	3	3
COAD	MSH6 →	-0.511	-2.584	<.001	.010	3	3
COAD	EGFR_pY1068 →	-0.336	-2.309	.009	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

PAI-1 by DACT1 expression — COAD

Explore this box plot interactively →